Current Issue February 2012, Vol. 8, No. 2
Feature Article
Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells
The purpose of this work is to study the antimetastasis activity of gadolinium metallofullerenol nanoparticles (f-NPs) in malignant and invasive human breast cancer models. We demonstrated that f-NPs inhibited the production of matrix metalloproteinase (MMP) enzymes and further interfered with the invasiveness of cancer cells in tissue culture condition.
Issue Highlights
Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imagingDrug delivery is an interdisciplinary and independent field of research and is gaining the attention of pharmaceutical researchers, medical doctors and industry. A safe and targeted drug delivery could improve the performance of some classic medicines already on the market, and moreover
Linear PEI nanoparticles: efficient pDNA/siRNA carriers in vitro and in vivoLinear polyethylenimine (lPEI, 25 kDa) nanoparticles' (LPN) series was synthesized by varying percentage of cross-linking with 1,4-butanediol diglycidyl ether (BDE) and their size, surface charge, morphology, pDNA protection/release, cytotoxicity and transfection efficiency were evaluated. Synthesized nanoparticles (NPs) were spherical in shape (size: ~109 – 235 nm; zeta potential: +38 to +16 mV).
Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisomeHypersensitivity reactions to liposomal drugs, often observed with Doxil and AmBisome, can arise from activation of the complement (C) system by phospholipid bilayers. To understand the mechanism of this adverse immune reaction called C activation-related pseudoallergy (CARPA), we analyzed the relationship among liposome features
Novel nanostructured lipid-dextran sulfate hybrid carriers overcome tumor multidrug resistance of mitoxantrone hydrochlorideNovel nanostructured lipid-dextran sulfate hybrid carriers (NLDCs) were successfully developed for sustained delivery of water-soluble cationic mitoxantrone hydrochloride (MTO) and overcoming multidrug resistance. The introduction of negative polymer of dextran sulfate sodium significantly improved the encapsulation efficiency (97.4%) and sustained the release of MTO (86.9% at 72 hours).
A novel dextran-oleate-cRGDfK conjugate for self-assembly of nanodrugWe report a novel synthetic biocompatible material: a conjugate with a fatty acid-substituted dextran decorated with cRGDfK peptide, which was used as a stable coating material instead of the conventional poly(ethylene glycol) for nanodrug preparation.
Gold-doxorubicin nanoconjugates for overcoming multidrug resistanceMultidrug resistance (MDR) is a major clinical obstacle to the success of cancer chemotherapy. Here we developed a gold-doxorubicin (DOX) nanoconjugates system to overcome MDR. Gold nanoparticles (AuNPs) were first PEGylated as Au-PEG-NH2, and DOX was then grafted onto AuNPs via a cleavable disulfide linkage (Au-PEG-SS-DOX).
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Initial Studies of Mechanical Compression on Neurogenesis with Neonatal Neural Stem Cells27 January 2012
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pH-Dependent Nanostructure Based on Isoquinoline-Cyclodextrin Conjugate for Thrombosis Therapy16 January 2012
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Improving interstitial transport of macromolecules through reduction in cell volume fraction in tumor tissues16 January 2012
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Electrostatic Assembly of a DNA Superparamagnetic Nanotool for Simultaneous Intracellular Delivery and In-Situ Monitoring16 January 2012
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Harnessing Nanoparticles to Improve Toxicity after Head and Neck Radiation16 January 2012
Multistability in platelets and their response to gold nanoparticles
Mechanism of anti-angiogenic property of gold nanoparticles: role of nanoparticle size and surface charge
